TIPS For Families

Brain Biology & Gambling

Written by: Janet Hanna
University of Nebraska-Lincoln Extension


The Biology of the Brain

The brain consists of billions of nerve cells organized by region and function.  Those cells communicate with one another through chemicals called neurotransmitters.  New research suggests that pathological gamblers have changes in the levels of neurotransmitter activity in parts of their brains.  It is not clear that these changes cause gambling – they could also be the effects of gambling – but further exploration of such changes could lead to new treatments.

Changes in the concentrations of some neurotransmitters are associated with such psychiatric illnesses as depression, anxiety, and obsessive-compulsive disorder.  In terms of pathological gambling, researchers are not yet certain which neurotransmitter changes may provide more understanding of and better treatments for the disorder.  However, there are neurotransmitters, especially those listed below, that are good candidates for more study.

Serotonin appears to help people control their impulses and need for excitement.  A reduced concentration of serotonin in the brain is associated with a decrease in the ability to control impulses.  That may lead people into risky behaviors, including gambling.  Medications that raise serotonin levels, such as Prozac and Zoloft, are effective treatments for depression.  They sometimes also help gamblers exercise more self-control.

Dopamine affects the way the brain experiences feelings of pleasure.  If doing something makes a person feel very good, the person usually wants to do that activity again and again.  Dopamine dysfunction appears to make people vulnerable to addictive behaviors.

Endorphins, chemicals the body makes, have the same effects on the brain that morphine and heroin do.  Endorphins create a feeling of well-being and relieve pain.  Several activities produce endorphins, including meditation and aerobic exercise.  That is the usual explanation for the “runner’s high.”  Exciting and risky activities, such as bungee jumping, also produce endorphins.  Endorphin production in the brains of gamblers may be one cause of their addiction.  Medicines that block the euphoria endorphins cause have been helpful to some gamblers.

Norepinephrine, or noradrenalin, affects energy, concentration, alertness, and sensation seeking.  Gamblers have been found to have increased levels of norepinephrine during gambling, and those levels stay elevated for extended periods – even after the gambler stops for the day.  These findings suggest that people with gambling problems may experience heightened levels of arousal while gambling, which may lead them to want more.

What Do These Findings Mean?

Learning about the brain biology of pathological gamblers gives researchers a way of understanding why gamblers have such a hard time stopping.  Perhaps the excitement and risk involved in gambling produce chemical changes that result in addiction.  If that is true, good intentions and willpower may not be enough.  It is reasonable to hope that in the future, the benefits of psychosocial treatment of pathological gambling – group therapy, Gamblers Anonymous, individual counseling, and family intervention – may be enhanced more often with medication.

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